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KMID : 0615720030200030177
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Jouranl of Korean Acupuncture and Moxibustion society
2003 Volume.20 No. 3 p.177 ~ p.193
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The Effects of 120Hz High Frequency Electroacupuncture on the Cold-Restraint-Induced Gastric Mucosal Damages
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Abstract
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Objective : The present studies investigated the effects of 120Hz high frequency electroacupunctue(EA) on the stress-induced stomach dysfunction in relation to its effect on the level of stress hormone and gastric mucosal damages. The gastric mucosal injury was induced by cold-restraint stress and two acupoints corresponding to Zusanli and Sanyinjiao in man were used.
Methods: Cold-restraint stress produced typical gastric lesions in all rats of the stressed groups, but he number of ulcers as well as the mean ulcer diameter were reduced by 120 Hz EA pre-treatment. The cold-restraint stress also induced an increase in catecholamine response involving epinephrine, norepinephrine and dopamine , but an slight decline were observed in EA pre-treated rats compared with cold-restrained rats.
Results: The degranulation value of gastric mast cell was significantly higher in cold-restrained rats than in control ones. However, with the significant reduction of degranulation values of gastric mast cells in EA pre-treated rats compared with cold-restrained ones, PGE_2 content in the gastric mucosa of EA pre-treated rats was also different form that observed in cold -restrained rats.
Cold-restraint stress induced an elevated mRNA expression of pro-inflammatory gene such as cyclooxygenases-2 and tumor necrosis factor(TNF)-a, but these expression were down-regulated in EA pre-treated rats.
Immunohistochemecal analysis showed that while the inhibitory-_kBa an TNF-_a immunoreaction in the surface epithelium of the stomach tended to increase, both reactions in the EA pre-treated rats showed similar pattern as observed in controls.
Conclusions : These results suggest that 120 Hz EA may act as a therapeutical means for gastric mucosal damages through a activation of pituitary adrenal system. it could be concluded that 120 hz high frequency electroacupuncture affords a good protective potential against stress-induce gastrointestinal dysfunction.
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